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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1977-1-25
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pubmed:abstractText |
The reaction of nerve endings in the median eminence of the rat to zinc iodide-osmium tetroxide (ZIO) staining was examined electron microscopically under normal and experimental conditions. The experimental condition of catecholamine exhaustion in the nerve endings was induced by the administration of H44/68 and reserpine. Vesicles in the terminals of catecholaminergic nerves reacted similarly to ZIO staining in both normal and experimental material. The majority of synaptic vesicles in various terminals gave a positive ZIO reaction. The neurosecretory elementary granules, however, failed to react with ZIO. On the other hand, some nerve terminals in the external layer of the median eminence showed a strong positive reaction in the cytoplasmic matrix, in mitochondria as well as in synaptic vesicles. These findings strongly suggest that the ZIO-positive substance in nerve terminals is not the transmitter itself, i.e. the monoamine, but rather represents a range of substances commonly found in various kinds of synaptic vesicles and is probably proteinaceous in nature. A brief discussion is also given on the difference in ZIO reactivity between neurosecretory elementary granules and small vesicles in the hypothalamo-hypophyseal tract.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catecholamines,
http://linkedlifedata.com/resource/pubmed/chemical/Iodides,
http://linkedlifedata.com/resource/pubmed/chemical/Methyltyrosines,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Osmium,
http://linkedlifedata.com/resource/pubmed/chemical/Reserpine,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0302-766X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
279-86
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:62620-Animals,
pubmed-meshheading:62620-Catecholamines,
pubmed-meshheading:62620-Female,
pubmed-meshheading:62620-Hypothalamo-Hypophyseal System,
pubmed-meshheading:62620-Iodides,
pubmed-meshheading:62620-Male,
pubmed-meshheading:62620-Median Eminence,
pubmed-meshheading:62620-Methyltyrosines,
pubmed-meshheading:62620-Microscopy, Electron,
pubmed-meshheading:62620-Microscopy, Fluorescence,
pubmed-meshheading:62620-Nerve Endings,
pubmed-meshheading:62620-Nerve Tissue Proteins,
pubmed-meshheading:62620-Osmium,
pubmed-meshheading:62620-Rats,
pubmed-meshheading:62620-Reserpine,
pubmed-meshheading:62620-Staining and Labeling,
pubmed-meshheading:62620-Zinc
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pubmed:year |
1976
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pubmed:articleTitle |
The zinc iodide-osmium tetroxide (ZIO) reaction on nerve endings in the median eminence of the rat under normal and experimental conditions.
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pubmed:publicationType |
Journal Article,
Comparative Study
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