Linked Life Data

6261443

Source:http://linkedlifedata.com/resource/pubmed/id/6261443

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-6-25
pubmed:abstractText
Fourteen rat islet tumours induced by streptozotocin and nicotinamide were examined by light microscopy with indirect immunoperoxidase staining and by electron microscopy. Most tumours consisted predominantly of B cells, but over a half of the tumours examined showed mixed cellularity with considerable numbers of A cells and small numbers of D or PP cells. Only 4 tumours consisted exclusively of B cells. There was no positive reaction for any kind of specific islet hormone antibodies in 2 tumours. Ultrastructurally, most tumours were composed of cells containing numerous secretory granules with B cell properties, with great variation in size, shape and number. We often encountered enterochromaffin-like cells or atypical granular cells or cells containing non-beta secretory granules. We could not identify, however, the ultrastructural counterparts of A or D cells. The results suggested that the multiplicity of the endocrine cells of rat islet cell tumours might be an expression of the cellular dedifferentiation of tumour cells which could re-differentiate into the whole range of components of the endocrine pancreas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-1227
pubmed:author
pubmed:issnType
Print
pubmed:volume
390
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-91
pubmed:dateRevised
2008-2-20
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Immunohistochemical and ultrastructural studies on rat islet cell tumours induced by streptozotocin and nicotinamide.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't