Linked Life Data

6261251

Source:http://linkedlifedata.com/resource/pubmed/id/6261251

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1981-6-13
pubmed:abstractText
We have found that human and ape ribosomal genes undergo concerted evolution involving genetic exchanges among nucleolus organizers on nonhomologous chromosomes. This conclusion is based upon restriction enzyme analysis of the ribosomal gene families in man and five ape species. Certain structural features were found to differ among (but not within) species even though the ribosomal genes have a multichromosomal distribution. Genetic exchanges among nucleolus organizer regions may be related to the well-known phenomenon of acrocentric chromosome associations observed in man and apes. Length variation in a region of the nontranscribed spacer was found in both chimpanzee species we examined. The nature of this length variation was found to be identical to that previously described in man. The origin of the length variation and its polymorphism within these three species might be explained by unequal alignment and unequal cross-over among the ribosomal genes. An especially surprising finding was a nucleotide sequence polymorphism present in each individual human and ape we examined. Some ribosomal genes of each individual have a HindII site in the 28S gene about 800 base pairs from the EcoRI site in this gene. The remaining 28S genes lack this HindII site. The presence of this polymorphism within individuals of every species we examined suggests that it has been maintained by natural selection.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-1009815, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-106129, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-1108767, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-113105, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-113106, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-1195397, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-1251186, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-13730523, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-13887466, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-14337503, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-159852, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-231673, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-281713, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-291033, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-364477, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-372561, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-374224, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-402222, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-415144, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-436453, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-439136, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-4391887, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-4508329, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-4687000, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-4853332, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-4859400, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-49260, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-4935105, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-5004308, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-5016971, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-5105183, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-5312501, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-537372, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-560255, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-560912, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-61844, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-6929543, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-6996571, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-70995, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-739545, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-787539, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-795295, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-809590, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-813561, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-822350, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-834278, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-881736, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-912752, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-913604, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261251-96940
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7323-7
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Molecular evidence for genetic exchanges among ribosomal genes on nonhomologous chromosomes in man and apes.
pubmed:publicationType
Journal Article, Comparative Study