Linked Life Data

6261016

Source:http://linkedlifedata.com/resource/pubmed/id/6261016

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-6-23
pubmed:abstractText
Infection of a chicken cell with avian sarcoma virus requires division of the infected cell before synthesis of infectious progeny is initiated. This requirement for a cell division for the complete expression of avian sarcoma virus has been examined further with chicken embryo fibroblasts infected with two distinct viruses. Chicken cells infected with and producing a mutant of Rous sarcoma virus temperature sensitive for transformation (tsLA24PR-A) were arrested in G0 by depletion of serum factors from growth medium. These stationary cells continued to produce infectious progeny in the absence of further cell division. Superinfection of the stationary cells with the wild-type Prague strain of Rous sarcoma virus (PR-RSV-C) produced a stable double infection in these cells. Progeny of the superinfecting PR-RSV-C, however, were not detected until these cells underwent division after stimulation with fresh serum-containing medium. The addition of colchicine to these serum-stimulated cells, although not affecting production of the tsLA24PR-A, inhibited the appearance of progeny of the superinfecting PR-RSV-C. These experiments indicate that each avian sarcoma virus infection of a chicken embryo fibroblast requires division of the infected cell for production of that virus regardless of whether or not the cell is already producing a similar virus. The results suggest, therefore, that the requirement for a cell division represents a requirement for an event that controls virus expression in a "cis-acting" fashion specific for the provirus.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-176421, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-196759, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-354499, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-4287698, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-4319842, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-4339198, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-4350228, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-4359305, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-4369144, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-4370277, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-5167847, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-6035643, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-67703, http://linkedlifedata.com/resource/pubmed/commentcorrection/6261016-916025
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
721-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Independent expression of avian sarcoma virus in doubly infected chicken embryo fibroblasts.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.