Linked Life Data

6260490

Source:http://linkedlifedata.com/resource/pubmed/id/6260490

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-6-13
pubmed:abstractText
1. Ammonium ion is shown to decrease the rate constants for Schiff's base formation and formation of a reduced intermediate during the catalytic cycle of benzylamine oxidase from pig plasma. The rat constant for reoxidation of the reduced intermediate is also inhibited whilst the rate constant for conversion of the oxidised enzyme form back to native enzyme is stimulated by ammonium ion. 2. Ammonium ion changes the electron paramagnetic resonance spectrum of the cupric centres in the enzyme, indicating that ammonia binds to the copper. 3. A catalytic mechanism for benzylamine oxidase is proposed on the basis of these and other results. This mechanism includes a novel step in which a hydroxyl coordinated to copper acts as a nucleophyle to facilitate hydride ion transfer to oxygen during the reoxidation process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0014-2956
pubmed:author
pubmed:issnType
Print
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139-44
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
A catalytic mechanism for benzylamine oxidase from pig plasma. Stopped-flow kinetic studies.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't