Linked Life Data

6259453

Source:http://linkedlifedata.com/resource/pubmed/id/6259453

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-5-13
pubmed:abstractText
The effectiveness of a recently developed isotopic in vivo assay for the measurement of delayed-type hypersensitivity (DTH) was compared to that of the conventional skin sensitization assay based on the ear-swelling index. DTH was measured in young and old C57BL/6 mice under conditions of normal health, spontaneous reticular cell sarcoma, Sendai virus infections and under the above conditions, while being treated with a potential immunorestorative agent, mercaptoethanol. A good correlation was observed between the two types of assay. However the reliability and sensitivity of the isotopic assay was found to be superior to the conventional skin sensitization assay. Thus, under optimum conditions, the swelling assay showed a 35% decline in DTH in old mice, and the isotopic assay a 62% decline.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0047-6374
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
In vivo evaluation of age-associated changes in delayed-type hypersensitivity.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.