Linked Life Data

6257786

Source:http://linkedlifedata.com/resource/pubmed/id/6257786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-4-13
pubmed:abstractText
Viral receptors are essential for the entry of the virus into the cell. EBV receptors can be detected on fresh lymphocytes by a technique that uses EBV-coupled tanned red blood cells that form rosettes with lymphocyte-bearing receptors. This technique was found to detect viral receptors only and not surface immunoglobulins. T cell depletion of the lymphocyte population showed that these receptors were present on B lymphocytes. Study of the presence of these EBV receptors on the surface of fresh lymphocytes from 66 subjects (age 2 to 66), selected out of a group of over 2000 individuals, showed that the majority of these donors had receptors for the virus. However, a few of these adults persistently failed to develop anti-EBV antibodies, even if they were in close contact with the infectious agent. The lymphocytes of 11 such individuals were found to be lacking EBV receptors. Transformation assay of these lymphocytes did not give rise to lymphoblastoid cell lines whereas lymphocytes from 4 individuals, who were EBV seropositive or seronegative but receptor positive, yielded permanent lymphoblastoid cell lines. This would suggest that a few EBV seronegative adults (less than 0.5%) display natural resistance to EBV transformation of their lymphoid cells as a result of absolute or relative lack of EBV receptors on these cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
897-900
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Relative lack of Epstein Barr virus (EBV) receptors on B cells from persistently EBV seronegative adults.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't