Linked Life Data

6257502

Source:http://linkedlifedata.com/resource/pubmed/id/6257502

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-4-24
pubmed:abstractText
One action of glucocorticoids is to enhance the tropic effect of catecholamines on heart muscle. To test the hypothesis that this action of glucocorticoids is mediated by modulation of beta-adrenergic receptors, we characterized and quantified myocardial beta-adrenergic receptors in adrenalectomized and glucocorticoid-replaced rats. Adrenalectomy was associated with an increase in myocardial beta-adrenergic receptors, as measured by [3H]dihydroalprenolol binding (P less than 0.001). This increase occurred by 6 h, with no difference over time to 7 days. The administration of cortisol (80 mg/kg.day) to adrenalectomized rats prevented the increase in beta-adrenergic receptors (P less than 0.01). The data indicate that glucocorticoids modulate myocardial beta-adrenergic receptors. However, these results do not support the hypothesis that glucocorticoid enhancement of catecholamine action is mediated by these changes, suggesting that glucocorticoids exert this action at a level other than the beta-adrenergic receptor site.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
977-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Glucocorticoid regulation of myocardial beta-adrenergic receptors.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.