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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1981-4-24
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pubmed:abstractText |
[125I]-[D-Ser(TBU)6]LHRH-EA binds to a single class of high affinity sites in rat anterior pituitary cells in culture at an apparent dissociation constant of 0.25 nM at 0-4C. The order of potency of a representative group of LHRH agonists and antagonists to displace the labeled ligand is similar to their LH-releasing activity. Treatment of pituitary cells for 48 h with 100 nM 5 alpha-dihydrotestosterone leads to a 40% decrease of the number of LHRH receptors with no change of binding affinity. This loss of LHRH receptors is accompanied by a similar decrease of the LH responsiveness to LHRH, thus providing the first evidence for a direct effect of sex steroids on pituitary LHRH receptors as a possible mechanism of feedback action.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0013-7227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
350-2
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6257490-Androgens,
pubmed-meshheading:6257490-Animals,
pubmed-meshheading:6257490-Binding, Competitive,
pubmed-meshheading:6257490-Binding Sites,
pubmed-meshheading:6257490-Cells, Cultured,
pubmed-meshheading:6257490-Dihydrotestosterone,
pubmed-meshheading:6257490-Female,
pubmed-meshheading:6257490-Gonadotropin-Releasing Hormone,
pubmed-meshheading:6257490-Kinetics,
pubmed-meshheading:6257490-Pituitary Gland, Anterior,
pubmed-meshheading:6257490-Rats,
pubmed-meshheading:6257490-Receptors, Cell Surface,
pubmed-meshheading:6257490-Receptors, LHRH
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pubmed:year |
1981
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pubmed:articleTitle |
Androgens decrease LHRH binding sites in rat anterior pituitary cells in culture.
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pubmed:publicationType |
Journal Article
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