Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1981-3-27
|
| pubmed:abstractText |
Because of potential significance of fecal mutagens in the pathogenesis of colon cancer, the dietary pattern and fecal mutagens of 3 populations with distinct risk for the development of colon cancer, a high-risk population in New York Metropolitan area (non-Seventh-Day Adventists), a low-risk population of vegetarian Seventh-Day Adventists in New York Metropolitan area and a low-risk population in rural Kuopio, Finland were studied. The average daily intake of protein was the same in the 3 groups, but the sources were different, a greater portion coming from meat in the New York non-Seventh-Day Adventists and from vegetables in Seventh-Day Adventists. The intake of fat was lower in Seventh-Day Adventists and higher in Kuopio and in New York non-Seventh-Day Adventists. The intake of dietary fiber was high in Kuopio compared to other groups. Fecal samples collected for 2 days were freeze-dried extracted with peroxide-free diethyl ether, partially purified on a silica-gel column and assayed for mutagenicity using the Salmonella/mammalian microsome mutagenicity test. The mutagenic activity was observed with Salmonella typhimurium tester strain TA98 without microsomal activation and with TA100 with and without microsomal activation in high-risk subjects from New York consuming a high-fat, high-meat diet. The incidence of fecal mutagen activity was higher in volunteers from New York consuming a high-fat, high-meat diet compared to low-risk rural Kuopio population. None of the vegetarian Seventh-Day Adventists showed any mutagenic activity.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0027-5107
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
72
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
511-22
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6256623-Adult,
pubmed-meshheading:6256623-Christianity,
pubmed-meshheading:6256623-Colon,
pubmed-meshheading:6256623-Colonic Neoplasms,
pubmed-meshheading:6256623-Diet,
pubmed-meshheading:6256623-Diet, Vegetarian,
pubmed-meshheading:6256623-Dietary Fats,
pubmed-meshheading:6256623-Dietary Fiber,
pubmed-meshheading:6256623-Disease Susceptibility,
pubmed-meshheading:6256623-Ethnic Groups,
pubmed-meshheading:6256623-Feces,
pubmed-meshheading:6256623-Finland,
pubmed-meshheading:6256623-Humans,
pubmed-meshheading:6256623-Male,
pubmed-meshheading:6256623-Meat,
pubmed-meshheading:6256623-Microsomes, Liver,
pubmed-meshheading:6256623-Middle Aged,
pubmed-meshheading:6256623-Mutagenicity Tests,
pubmed-meshheading:6256623-Mutagens,
pubmed-meshheading:6256623-New York City,
pubmed-meshheading:6256623-Salmonella typhimurium
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
Metabolic epidemiology of large bowel cancer. Fecal mutagens in high- and low-risk population for colon cancer. A preliminary report.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|