Linked Life Data

625580

Source:http://linkedlifedata.com/resource/pubmed/id/625580

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-4-17
pubmed:abstractText
The oxidation of the naphthalene ring system of propranolol by the rat liver 9000g supernatant has been studied by gas chromatography-mass spectrometry. Two dihydroxy metabolites, one of which possibly catechol-like, and four monophenols were identified based on the mass fragmentation pattern and retention times of their trimethylsilyl and d9-trimethylsilyl derivatives. These observations emphasize the complex oxidation pattern of this drug. All metabolites identified are proposed to be associated with significant biological activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Formation of catechol-like and monophenolic metabolites of propranolol by the rat liver 9000G supernatant.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.