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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4478
|
|
pubmed:dateCreated |
1981-2-26
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|
pubmed:abstractText |
Information processing in the vertebrate retina occurs in two separate channels known as ON and OFF channels. When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. 2-Amino-4-phosphonobutyric acid blocks the light response of the ON bipolar cell by mimicking the endogenous photoreceptor transmitter.
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|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0036-8075
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
9
|
|
pubmed:volume |
211
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
182-5
|
|
pubmed:dateRevised |
2008-11-21
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|
pubmed:meshHeading |
pubmed-meshheading:6255566-Action Potentials,
pubmed-meshheading:6255566-Aminobutyric Acids,
pubmed-meshheading:6255566-Animals,
pubmed-meshheading:6255566-Light,
pubmed-meshheading:6255566-Necturus,
pubmed-meshheading:6255566-Organophosphorus Compounds,
pubmed-meshheading:6255566-Receptors, Neurotransmitter,
pubmed-meshheading:6255566-Retina,
pubmed-meshheading:6255566-Vision, Ocular
|
|
pubmed:year |
1981
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|
pubmed:articleTitle |
2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research.
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|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|
