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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1981-2-26
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pubmed:abstractText |
Formation of viral closed circular supercoiled DNA duplexes and production of progeny virus were both inhibited in cultured mouse cells treated with cycloheximide in the first 4 h of type C retrovirus infection. With different doses of cycloheximide to cause different degrees of inhibition, the number of viral supercoiled DNA duplexes detected in the cells at 11 h showed an apparent correlation with the amount of progeny virus produced in the 12- to 22-h period of infection. A slight accumulation of the full-genome linear duplex and an open circular duplex of viral DNA intermediate was observed in the cycloheximide-treated cells. Cycloheximide given to the cells during the time of conversion of viral DNA from linear to supercoiled duplex forms (6 to 11 h after virus inoculation) did not inhibit the conversion. These kinetic data suggest that a cycloheximide-sensitive metabolic process, probably early viral protein synthesis, is required for retrovirus replication and supercoiled viral DNA formation in the cell.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-1054828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-1134557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-117118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-163973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-170417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-178885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-178898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-183818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-185393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-185796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-189496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-189933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-192459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-202729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-211261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-291003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-291033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-4099080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-4137585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-414220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-4291934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-4358074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-4361674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-4363246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-455438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-556779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-58074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-6245227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-6248878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-66066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-77908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-845942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-88264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255205-994300
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6255205-Animals,
pubmed-meshheading:6255205-Cell Line,
pubmed-meshheading:6255205-Cyclophosphamide,
pubmed-meshheading:6255205-DNA, Circular,
pubmed-meshheading:6255205-Depression, Chemical,
pubmed-meshheading:6255205-Dose-Response Relationship, Drug,
pubmed-meshheading:6255205-Kidney,
pubmed-meshheading:6255205-Mice,
pubmed-meshheading:6255205-Mice, Inbred BALB C,
pubmed-meshheading:6255205-Retroviridae
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pubmed:year |
1980
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pubmed:articleTitle |
Covalently closed circular DNAs of murine type C retrovirus: depressed formation in cells treated with cycloheximide early after infection.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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