Linked Life Data

6255010

Source:http://linkedlifedata.com/resource/pubmed/id/6255010

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1981-2-24
pubmed:abstractText
Evidence has been presented suggesting the presence of vitamin D(3) 3beta-glucosiduronate and 1,25-dihydroxyvitamin D(3) glucosiduronate in rat bile. To evaluate the role of vitamin D glucosiduronates in calcium and phosphorus homeostasis, we synthesized vitamin D(3) 3beta-glucosiduronate and tested its biological activity in calcium- and vitamin D-deficient rats. After the intravenous administration of vitamin D(3) 3beta-glucosiduronate to rats maintained on a low calcium diet, there was an increase in duodenal calcium transport and an increase in serum calcium. Vitamin D(3) 3beta-glucosiduronate, however, was less active than equimolar amounts of vitamin D(3). At doses of less than 0.65-1 nmol per rat, the conjugate exhibited no activity. When vitamin D(3) 3beta-glucosiduronate was administered to vitamin D-deficient rats, 25-hydroxyvitamin D was detected in the serum; the increase in serum 25-hydroxyvitamin D levels was less than that observed after the administration of an equimolar amount of vitamin D(3). Vitamin D(3) 3beta-glucosiduronate showed no detectable activity in the induction of calcium binding protein in chick embryonic duodena, a system in which no endogenous steroid beta-glucuronidase activity is detectable. These data demonstrate that vitamin D(3) 3beta-glucosiduronate is biologically active in vivo and that the observed activity is due to hydrolysis of the conjugate to vitamin D(3). As vitamin D(3) 3beta-glucosiduronate is excreted in the bile of rats, it is possible that this conjugate is reutilized in vivo after hydrolysis to free vitamin D(3). These results suggest the existence of a mechanism for reutilization of the biliary products of vitamin D(3).
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-1153436, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-1190788, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-1276151, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-14347953, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-218059, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-35579, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-4290687, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-429557, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-4311438, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-5295921, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-5790824, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-649607, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-6967504, http://linkedlifedata.com/resource/pubmed/commentcorrection/6255010-7356679
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1274-80
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Role of vitamin D glucosiduronate in calcium homeostasis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't