Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1981-1-26
pubmed:abstractText
A transformation-defective mutant of Abelson murine leukemia virus (A-MuLV), called A-MuLV-P92td, has been isolated. The mutant encodes a serologically identifiable A-MuLV protein of molecular weight 92,000 (P92) but it lacks the ability to transform either fibroblasts or bone marrow lymphoid cells. In contrast to the protein made by transforming strains of A-MuLV, the protein made by A-MuLV-P92td does not becme phosphorylated during in vitro incubation with [gamma-32P]ATP. If the protein is mixed with proteins from cells transformed by a functional A-MuLV strain, phosphorylation of P92 occurs, showing that its ability to accept phosphate is not altered by the mutation. These parallel changes provide genetic evidence that the A-MuLV protein is a transforming protein and that its associated protein kinase activity (EC 2.7.1.37) is a crucial part of its transforming ability.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-163444, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-168584, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-178822, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-205879, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-206646, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-209468, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-211510, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-215207, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-215208, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-218212, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-222460, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-223152, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-224582, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-226974, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-228858, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-229973, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-229975, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-233116, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-397920, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-4850204, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-4918190, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-4925356, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-6243819, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-6244493, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-6245237, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-6246487, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-78989, http://linkedlifedata.com/resource/pubmed/commentcorrection/6254050-92572
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4993-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't