rdf:type |
|
lifeskim:mentions |
umls-concept:C0014298,
umls-concept:C0205314,
umls-concept:C0205460,
umls-concept:C0243071,
umls-concept:C0441655,
umls-concept:C0598132,
umls-concept:C0679622,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636
|
pubmed:issue |
10
|
pubmed:dateCreated |
1980-12-18
|
pubmed:abstractText |
Novel tri- and tetrapeptide analogues of enkephalin, in conjunction with earlier structure-activity data, confirm that chemical substitutents present in the first and fourth residues of enkephalin are required for in vitro biological activity. A class of arylamino and alkylamino derivatized tripeptides also were found to have significant in vitro opioid-like activity indistinguishable from [D-Ala2,D-Leu5]enkephalin and morphine.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0022-2623
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
23
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1113-22
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:6252322-Animals,
pubmed-meshheading:6252322-Bacitracin,
pubmed-meshheading:6252322-Binding, Competitive,
pubmed-meshheading:6252322-Brain,
pubmed-meshheading:6252322-Chromatography, High Pressure Liquid,
pubmed-meshheading:6252322-Endorphins,
pubmed-meshheading:6252322-Enkephalins,
pubmed-meshheading:6252322-Guinea Pigs,
pubmed-meshheading:6252322-Muscle, Smooth,
pubmed-meshheading:6252322-Muscle Contraction,
pubmed-meshheading:6252322-Naloxone,
pubmed-meshheading:6252322-Rats,
pubmed-meshheading:6252322-Receptors, Opioid,
pubmed-meshheading:6252322-Structure-Activity Relationship
|
pubmed:year |
1980
|
pubmed:articleTitle |
Novel analogues of enkephalin: indentification of functional groups required for biological activity.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|