rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1980-12-18
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pubmed:abstractText |
Cytochalasin B greatly enhances secretion of beta-glucuronidase and generation of superoxide on stimulation of rabbit peritoneal neutrophils with the soluble chemotactic factor N-formylmethionylleucylphenylalanine (f-Met-Leu-Phe). There are smaller changes due to cytochalasin B on binding of f-Met-Leu-[(3)H]-Phe, stimulation of phosphatidylinositol turnover and the stimulated increase in the permeability of the cell membrane to Ca(2+). These latter changes are probably artefactual and arise as secondary consequences of cell stimulation. Our observations support the notion that changes in Ca(2+) permeability of membranes and stimulation of phosphatidylinositol turnover reflect early stages in the sequence of events initiated by f-Met-Leu-Phe binding to its receptor and which lead to cell activation phenomena such as secretion and superoxide production.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochalasin B,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronidase,
http://linkedlifedata.com/resource/pubmed/chemical/N-Formylmethionine,
http://linkedlifedata.com/resource/pubmed/chemical/N-Formylmethionine...,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositols,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Formyl Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-3002
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
601
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
584-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6251879-Animals,
pubmed-meshheading:6251879-Calcium,
pubmed-meshheading:6251879-Cell Membrane,
pubmed-meshheading:6251879-Chemotactic Factors,
pubmed-meshheading:6251879-Cytochalasin B,
pubmed-meshheading:6251879-Glucuronidase,
pubmed-meshheading:6251879-N-Formylmethionine,
pubmed-meshheading:6251879-N-Formylmethionine Leucyl-Phenylalanine,
pubmed-meshheading:6251879-Neutrophils,
pubmed-meshheading:6251879-Oligopeptides,
pubmed-meshheading:6251879-Phosphatidylinositols,
pubmed-meshheading:6251879-Rabbits,
pubmed-meshheading:6251879-Receptors, Cell Surface,
pubmed-meshheading:6251879-Receptors, Formyl Peptide,
pubmed-meshheading:6251879-Superoxides
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pubmed:year |
1980
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pubmed:articleTitle |
Use of cytochalasin B to distinguish between early and late events in neutrophil activation.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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