| pubmed-article:6251132 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6251132 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:6251132 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:6251132 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:6251132 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:6251132 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:6251132 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6251132 | pubmed:dateCreated | 1980-11-20 | lld:pubmed |
| pubmed-article:6251132 | pubmed:abstractText | Viral infections are often associated with immunodeficiency states. Although T lymphocytes have been thought to suppress the host's response, the precise etiology remains unclear. Therefore, we characterized T lymphocytes from six patients during both acute and convalescent phases of infectious mononucleosis (IM) with monoclonal antibodies (titer, 10(-5) to 10(-7) to antigens restricted to the TH2- helper (T4) and TH2 suppressor (T5) T cell subsets as well as to a common T cell antigen (T3) and HLA-D related Ia antigens. It was found that during acute infectious mononucleosis, there is both activation and increase of suppressor T cells (T5+, Ia+ phenotype). Fuctionally, the acute IM lymphocytes suppress autologous T cell proliferation to antigens as well as pokeweed mitogen driven B cell immunoglobulin production. In contrast, convalescence is associated with a return to normal of T cell subsets and immune function. These results demonstrate that viral infections can preferentially activate a specific T cell subset and suppress the overall human immune response. | lld:pubmed |
| pubmed-article:6251132 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6251132 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6251132 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6251132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6251132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6251132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6251132 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6251132 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6251132 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6251132 | pubmed:author | pubmed-author:SchlossmanS... | lld:pubmed |
| pubmed-article:6251132 | pubmed:author | pubmed-author:ReinherzE LEL | lld:pubmed |
| pubmed-article:6251132 | pubmed:author | pubmed-author:O'BrienCC | lld:pubmed |
| pubmed-article:6251132 | pubmed:author | pubmed-author:RosenthalPP | lld:pubmed |
| pubmed-article:6251132 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6251132 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:6251132 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6251132 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6251132 | pubmed:pagination | 1269-74 | lld:pubmed |
| pubmed-article:6251132 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:6251132 | pubmed:meshHeading | pubmed-meshheading:6251132-... | lld:pubmed |
| pubmed-article:6251132 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6251132 | pubmed:articleTitle | The cellular basis for viral-induced immunodeficiency: analysis by monoclonal antibodies. | lld:pubmed |
| pubmed-article:6251132 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6251132 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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