Linked Life Data

6250675

Source:http://linkedlifedata.com/resource/pubmed/id/6250675

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-11-25
pubmed:abstractText
The neurochemical consequences of unilateral olfactory bulbectomy (UBX) in mice were determined in the remaining olfactory bulb at various times after surgery. The most significant finding was a progressive decline in opiate ligand (dihydromorphine) and naloxone) binding that appeared within 11 days after surgery and persisted throughout the study. Statistically significant declines in spiroperidol (-67%), clonidine (-48%) and muscimol (-16%) binding were also observed 90 days after surgery. At 180 days postsurgery we observed a 20% increase in diazepam binding. No effect of UBX on dihydroalprenolol, quinucludinylbenzilate or serotonin ligand binding was observed. Bulbectomy resulted in a moderate decrease (-28%) in DOPA decarboxylase activity 14 days after surgery, which returned to normal by 30 days. Glutamic acid decarboxylase activity decreased by 37% 7 days after UBX, returned to normal by 14 days after surgery and then increased by 25% 90 days after UBX. Unilateral bulbectomy had no effect on cholineacetyltransferase activity in the remaining bulb. Thus, following a unilateral procedure, one bulb cannot necessarily serve as a valid control for the other. Possible explanations for the neurochemical changes observed are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
199
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-47
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Influence of unilateral olfactory bulbectomy on opiate and other binding sites in the contralateral bulb.
pubmed:publicationType
Journal Article