Linked Life Data

6248805

Source:http://linkedlifedata.com/resource/pubmed/id/6248805

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-9-26
pubmed:abstractText
We measured adrenal weights 3 days after left- or sham-adrenalectomy in male Sprague-Dawley rats at 10 ages between 10 and 155 days. Compared to sham-operated rats, the magnitude of the increase in right adrenal weight ranged between 19 and 32% after unilateral adrenalectomy and was significant at 10, 20, 40, 50, and 60 days (p less than 0.01). Comparing left with right adrenals in unilaterally adrenalectomized rats, the right was heavier at all ages (p less than 0.01); in animals 40 days and younger, this is due to normal adrenal growth rate (0.3 mg/day) as well as compensatory adrenal growth, while in older animals normal growth rate is slow (0.04 mg/day) and this difference in left and right adrenal weights is due primarily to compensatory growth. We conclude from this study that compensatory adrenal growth occurs 3 days after left adrenalectomy at all ages except 15 and 30 days. Resting levels of plasma ACTH and corticosterone did not differ between left- and sham-adrenalectomized rats at any age. The ACTH response to 1 min exposure to ether vapors was markedly reduced in 7- and 12-day-old rats (p less than 0.01). We conclude that compensatory adrenal growth is a consistent response 3 days after unilateral adrenalectomy that depends neither on the age at which surgery is performed nor on the capacity of the rat to secrete markedly elevated levels of ACTH.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
34-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Compensatory adrenal growth in immature and mature male rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.