Linked Life Data

6246809

Source:http://linkedlifedata.com/resource/pubmed/id/6246809

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1980-7-22
pubmed:abstractText
When rats were fed isocaloric amounts of chemically defined diets with variable amounts of protein (8-60%) or fat (0-30%) over a 10-day period, their serum and antral gastrin concentrations were, respectively, 60 and 40% lower than the levels of chow-fed rats. It was also determined that neither the low bulk content of these diets nor their inability to adequately buffer the gastric pH contributed to this response. The time course of this dietary-induced reduction in gastrin levels was investigated and it was found that the serum hormone levels were significantly reduced as early as 1-2 h after chow-fed rats were placed on these chemically defined diets. Antral gastrin levels were maintained at normal levels for 4-5 days after rats started consuming these synthetic diets and fell thereafter. With all of the chemically defined diets tested, the gastrin secretory response to a meal was significantly reduced. It therefore appears that synthetic diets lack some undefined food constituent present in chow that is required for the normal postprandial release of gastrin or, alternatively, that they contain an inhibitory factor which blocks the normal secretory response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
238
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G376-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Effect of chemically defined diets on antral and serum gastrin levels in rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.