Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-7-22
pubmed:abstractText
The morphologic changes in the livers of autopsy specimens from recipients of 62 allogeneic bone marrow transplants were reviewed and characterized in specimens from patients who had had apparent drug toxicity, graft-versus-host disease (GVHD), and disseminated cytomegalovirus (CMV) infection. Two conditioning protocols were associated with significant hepatic toxicity. Two of 3 recipients on whom autopsies were performed who had been prepared with high doses of carmustine, cyclophosphamide, and total body irradiation had undergone acute hepatic failure and submassive necrosis with periportal sparing. Seven of 9 patients prepared with busulfan (16 or 20 mg/kg) and cyclophosphamide had moderate to marked centrilobular sinusoidal fibrosis and associated hepatocellular atrophy and necrosis. Twenty of the patients had acute cutaneous GVHD with associated hepatic dysfunction, including 8 with disseminated CMV infection. Of the 12 patients without concomitant CMV infection, 5 had an early onset of GVHD and had predominantly periportal and focal midzonal hepatocellular necrosis, and 7 had acute GVHD with later onset with predominantly bile duct injury. Fifteen patients had evidence of disseminated CMV infection. Whereas CMV infection alone was associated with both hepatocellular and bile duct injury, detectable virus infection was not a requirement for hepatocellular or bile duct injury associated with GVHD.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-1062231, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-1068643, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-11596, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-13147641, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-13909967, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-14866, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-21931, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-219406, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-23008, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-234595, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-234706, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-25684, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-266839, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-26718, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-272822, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-28592, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-30044, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-34319, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-356266, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-36019, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4107389, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4153962, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4155153, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4156507, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4286992, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4358428, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4397431, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4398426, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4404985, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4616840, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4852251, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4886081, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-4977625, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-5214802, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-5215519, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-5280623, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-5321149, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-5327788, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-56872, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-5858571, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-793117, http://linkedlifedata.com/resource/pubmed/commentcorrection/6246804-920871
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
369-86
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Pathology of the liver with bone marrow transplantation. Effects of busulfan, carmustine, acute graft-versus-host disease, and cytomegalovirus infection.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.