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pubmed-article:6246498pubmed:abstractTextQuantal events have been analyzed at a neuro-neuronal synapse of Aplysia where the nature of the transmitter is established and both presynaptic and postsynaptic neurons are identified and can be voltage-clamped. Prolonged depolarizations were applied to the presynaptic neuron, which gave rise in the postsynaptic cell to a current response characterized by current fluctuations or noise. Acetylcholine was also applied ionophoretically on the same postsynaptic cell. Amplitude and time course of miniature currents and acetylcholine-activated chloride channels of the same cell were examined by using a current fluctuation analysis. It was estimated that one presynaptic spike releases about 180 quanta, each opening 500 chloride channels.lld:pubmed
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pubmed-article:6246498pubmed:articleTitleQuantal release of acetylcholine examined by current fluctuation analysis at an identified neuro-neuronal synapse of Aplysia.lld:pubmed
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