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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1980-6-25
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pubmed:abstractText |
Two modes of transmission of ecotropic type C viruses occur naturally in C57BL mice: maternal (i.e., through milk) and genetic. By selection of virus-positive and virus-negative B10.ASgSn [B10.A (H-2a)] mothers and foster-nursing of C57BL/10ScSn [B10 (H-2b)] newborns, four sublines of C57BL mice were obtained: B10.A V+, B10.A V-, B10 V+, and B10 V-. (V+ denotes positive for milk-transmitted B-tropic virus; V- denotes negative for milk-transmitted B-tropic virus). Milk transmission of naturally prevalent B-tropic virus (V+ sublines) led to persistent infection of all offspring over at least 8 generations. Milk transmission of virus was associated with a very high incidence of lymphomas. The H-2 complex influenced the titers of virus after milk transmission, which were higher in B10.A V+ mice than in B10 V+ mice. H-2 control of virus titers, as measured by serum p30 assay, was confirmed in (B10.A V+ X B10 V+)F2 mice. Resistance to the virus was dominant, because serum p30 levels in F1 and H-2a/b F2 animals were similar to those in the B10 V+ subline and lower than those in the B10.A V+ subline. The H-2 complex also influenced the incidence of lymphomas (78 and 42%, respectively, in the B10.A V+ and B10 V+ sublines). Most B10.A V+ lymphomas were of T-cell origin, whereas most B10 V+ lymphomas were classified as non-T/non-B cells. Genetic transmission of virus (V- sublines) led to heterogeneous expression of both N- and B-tropic viruses, which thereby established the mottled trait for expression of genetically transmitted type C viruses in C57BL mice. Genetic transmission was associated with a low incidence of lymphomas that occurred in senescence.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8874
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1179-89
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:6245301-Age Factors,
pubmed-meshheading:6245301-Aging,
pubmed-meshheading:6245301-Animals,
pubmed-meshheading:6245301-B-Lymphocytes,
pubmed-meshheading:6245301-Female,
pubmed-meshheading:6245301-H-2 Antigens,
pubmed-meshheading:6245301-Lactation,
pubmed-meshheading:6245301-Leukemia Virus, Murine,
pubmed-meshheading:6245301-Lymphoma,
pubmed-meshheading:6245301-Male,
pubmed-meshheading:6245301-Mice,
pubmed-meshheading:6245301-Mice, Inbred C57BL,
pubmed-meshheading:6245301-Milk,
pubmed-meshheading:6245301-Neoplasms, Experimental,
pubmed-meshheading:6245301-Pedigree,
pubmed-meshheading:6245301-Pregnancy,
pubmed-meshheading:6245301-Sex Factors,
pubmed-meshheading:6245301-Spleen,
pubmed-meshheading:6245301-T-Lymphocytes,
pubmed-meshheading:6245301-Viral Proteins
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pubmed:year |
1980
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pubmed:articleTitle |
Naturally occurring leukemia viruses in H-2 congenic C57BL mice. I. High lymphoma incidence following milk-borne transmission of virus.
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pubmed:publicationType |
Journal Article
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