Linked Life Data

62443

Source:http://linkedlifedata.com/resource/pubmed/id/62443

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1976-12-23
pubmed:abstractText
In a first step of our investigation the staining characteristics, especially the argyrophilia and metachromasia, of immunohistologically identified endocrine cells of the pancreatic islets and of the gastroduodenal mucosa were tested. These staining characteristics were then examined on insulinomas and gastrinomas. Contrary to normal B cells which generally react positively with aldehyde fuchsin and pseudoisocyanine but not argyrophilic with the Grimelius method, the neoplastic B cells give inconsistent results with conventional staining methods. Yet neoplastic B cells often show argyrophilic structures. Immunohistologically, most benign insulinomas are rich in insulin-containing cells, whereas in malignant types such cells are rare. The carcinomas, however, show a typical and distinct Grimelius argyrophilia. The tumor cells of gastrinomas are Grimelius argyrophilic and slightly metachromatic, as normal G cells, yet, contrary to A1 cells, they are only exceptionally stainable with the Hellerström method. Despite the great number of Grimelius positive tumor cells, generally only a few reacted with antigastrin serum. Nevertheless, the immunohistology is the most reliable method for the diagnosis of gastrinomas. Electron microscopic results are often difficult to interpret, since gastrinomas, as well as undifferentiated or malignant insulinomas, may predominantly contain atypical secretion granules.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0340-1227
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
371
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-50
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Histologic characteristics of insulinomas and gastrinomas. Value of argyrophilia, metachromasia, immunohistology, and electron microscopy for the identification of gastrointestinal and pancreatic endocrine cells and their tumors.
pubmed:publicationType
Journal Article