Linked Life Data

6244171

Source:http://linkedlifedata.com/resource/pubmed/id/6244171

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-5-23
pubmed:abstractText
Experiments performed to demonstrate the participation of cholinergic synapses in retinal spreading depression (SD) have shown that: (1) acetylcholine (ACh) is liberated during SD, its concentration increasing up to 10(-4) mM in the superfusate of one eye cup; (2) the susceptibility of the retina to SD and the velocity of propagation of circling SD are influenced by cholinergic and anticholinergic drugs. ACh 1 mM is effective in eliciting the reaction, whereas d-tubocurarine 0.01 mM and atropine 0.25 mM block this effect. Prostigmine 0.075 mM is able to trigger the reaction and also potentiates the effect of ACh. The velocity of propagation is decreased by ACh 0.25-1.0 mM and prostigmine 0.030 mM, which also potentiate this effect of ACh. Pulses of d-tubocurarine 0.005-0.030 mM and atropine 0.025-0.30 mM decrease the velocity of propagation. However, they block the effect of ACh if they are continuously present in the superfusing solution; (3) the effects of ACh are not blocked by tetrodotoxin 3.19 x 10(-3) mM.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-4819
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-36
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Cholinergic neurotransmission in retinal spreading depression.
pubmed:publicationType
Journal Article