Linked Life Data

6242444

Source:http://linkedlifedata.com/resource/pubmed/id/6242444

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-4
pubmed:dateCreated
1985-12-18
pubmed:abstractText
A newly identified calcium binding protein called chondrocalcin with two subunits of molecular weight approximately 35 000 has been studied in bovine, rat and human cartilage matrix using a monospecific polyclonal antibody. Although it is present in small amounts in non-calcifying cartilage, it occurs in local high concentrations wherever cartilage calcification is observed, namely in the calcifying part of the growth plate and in calcified articular cartilage. Immunoelectron microscopy revealed that it is present in exactly the same discrete sites where mineral is first detected. Thus it may act as a nucleating agent for apatite formation. It is deposited in the same sites where unusual local high concentrations of proteoglycan and link protein are detected by immunoelectron microscopy. Chondrocalcin may bind either directly or indirectly to these molecules. Its occurrence within hypertrophic chondrocytes immediately prior to its extracellular appearance suggests that it is synthesised and released by these cells. Its absence from osteoid during intramembranous calcification indicates a selective involvement in endochondral calcification.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0236-5383
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The association of a newly discovered protein, called chondrocalcin, with cartilage calcification.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't