|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1985-12-19
|
|
pubmed:abstractText |
The establishment of permanent acute lymphocytic leukemia (ALL) lines of different phenotypes permits the study of their sensitivity to chemotherapeutic agents. The sensitivity of four ALL cell lines, two T-cell lines and one each of B- and non-T/non-B cell lines, to eight chemotherapeutic agents was studied by means of clonogenic assay. Response data were analyzed by two criteria--one based on concentrations obtainable from the elimination phase and the other based on peak concentration--both derived from pharmacokinetic studies in man. The overall correlation between the two criteria was good and only in 5 of 32 occasions were there major discrepancies. A retrospective analysis of the clinical course of the four donor patients showed that although the one set of criteria gave a positive correlation of asparaginase response in vivo, the other positively correlated the daunorubicin response, but not vice versa. No new cut-off line could be drawn to satisfy completely in vitro/in vivo correlation for all the drugs. Although the possibility exists that a leukemic cell line may not actually be predictive of chemotherapeutic responsiveness in the donor patients, our data indicate a need to reexamine the in vitro system in predictive testing of antileukemic agents.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0732-9482
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
307-19
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6242352-Adult,
pubmed-meshheading:6242352-Antineoplastic Agents,
pubmed-meshheading:6242352-Asparaginase,
pubmed-meshheading:6242352-Cell Survival,
pubmed-meshheading:6242352-Cells, Cultured,
pubmed-meshheading:6242352-Child,
pubmed-meshheading:6242352-Colony-Forming Units Assay,
pubmed-meshheading:6242352-Daunorubicin,
pubmed-meshheading:6242352-Dexamethasone,
pubmed-meshheading:6242352-Dose-Response Relationship, Drug,
pubmed-meshheading:6242352-Doxorubicin,
pubmed-meshheading:6242352-Female,
pubmed-meshheading:6242352-Humans,
pubmed-meshheading:6242352-Hydrocortisone,
pubmed-meshheading:6242352-Leukemia, Lymphoid,
pubmed-meshheading:6242352-Male,
pubmed-meshheading:6242352-Middle Aged,
pubmed-meshheading:6242352-Tumor Stem Cell Assay,
pubmed-meshheading:6242352-Vinblastine,
pubmed-meshheading:6242352-Vincristine,
pubmed-meshheading:6242352-Zinostatin
|
|
pubmed:year |
1984
|
|
pubmed:articleTitle |
Chemotherapeutic sensitivity of acute lymphoblastic leukemia cells in culture: correlation with clinical efficacy on donor patients.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
