Linked Life Data

6242342

Source:http://linkedlifedata.com/resource/pubmed/id/6242342

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
72
pubmed:dateCreated
1985-10-29
pubmed:abstractText
The syngeneic mixed lymphocyte reaction (SMLR) is the proliferative response of T lymphocytes cultured with non-T lymphocytes. Normal mouse serum supports proliferative activity in the SMLR comparable to levels observed when fetal calf serum is used. Thus, the SMLR does not appear to be a response to xenogeneic antigens. The ontogeny and senescence of the SMLR was also studied. The SMLR is impaired in mice less than 4 weeks of age but attains adult levels of activity at 4 weeks of age. The SMLR is also impaired in 24-month-old mice. These impairments were observed regardless of the source of serum used in the cultures. Finally, monoclonal antibodies have been developed which identify a subpopulation of spleen cells which respond in the SMLR. In indirect immunofluorescence these antibodies stain 50-80% of cells activated in the SMLR, but only 5-8% of spleen cells or cells activated in the allogeneic MLR. These antibodies block the proliferative response in the SMLR but do not interfere with the response to alloantigens or PHA.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0301-0457
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-16
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The developmental biology of the syngeneic mixed lymphocyte reaction.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.