Linked Life Data

6241931

Source:http://linkedlifedata.com/resource/pubmed/id/6241931

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1985-5-24
pubmed:abstractText
Subpopulations tumour-infiltrating lymphocytes were studied in 13 patients with colorectal carcinoma using cryostat immunohistochemistry. Murine monoclonal antibodies (MAB) to the surface phenotype of lymphocyte subpopulation were used in an indirect immunoperoxidase method to demonstrate T (MAB OKT3), T helper (MAB OKT4), T suppressor (MAB OKT8) and B lymphocytes (MAB B1). Langerhans cells were demonstrated using MAB OKT6. All cells reacting with each monoclonal antibody were more prevalent in the stroma of the tumour than within the sheets of malignant cells. In both these areas, OKT8-positive cells were significantly more numerous than OKT4-positive cells, as estimated quantitatively by point counting on a fixed grid. In uninvolved areas of normal mucosa, OKT4-positive lymphocytes were in the majority. OKT6-positive cells were present in large numbers within tumour cells and in close association with lymphoid aggregates. The presence of large numbers of OKT8-positive cells in situ in human colorectal carcinomas may be a cellular mechanism in favour of tumour growth. OKT6-positive cells in situ suggest that mechanisms for antigen processing and presentation are well represented in human colorectal carcinomas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0251-1789
pubmed:author
pubmed:issnType
Print
pubmed:volume
4 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
60-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
In situ subpopulations of lymphocytes in human colorectal carcinomas.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't