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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3-4
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pubmed:dateCreated |
1985-2-4
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pubmed:abstractText |
The putative 5-HT agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT) produced in rats an increase in the number of shocks accepted in a modified Vogel's conflict test design. Subchronic pretreatment with p-chlorophenylalanine (PCPA) similarly caused release of the punished behavior. This anticonflict effect of PCPA was antagonized by both 5-hydrotryptophan and 8-OH-DPAT. Thus in naive animals 8-OH-DPAT exerting anticonflict effects acted like a 5-HT antagonist, whereas in subchronically PCPA-pretreated animals with presumably supersensitive 5-HT receptors, 8-OH-DPAT decreasing the number of accepted shocks acted like a 5-HT agonist.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-2999
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
365-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6239785-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:6239785-Animals,
pubmed-meshheading:6239785-Conflict (Psychology),
pubmed-meshheading:6239785-Fenclonine,
pubmed-meshheading:6239785-Male,
pubmed-meshheading:6239785-Naphthalenes,
pubmed-meshheading:6239785-Rats,
pubmed-meshheading:6239785-Rats, Inbred Strains,
pubmed-meshheading:6239785-Receptors, Serotonin,
pubmed-meshheading:6239785-Tetrahydronaphthalenes
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pubmed:year |
1984
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pubmed:articleTitle |
Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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