Linked Life Data

623941

Source:http://linkedlifedata.com/resource/pubmed/id/623941

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1978-4-17
pubmed:abstractText
1 The responses of the guinea-pig taenia coli, urinary bladder, and the rabbit portal vein to ultraviolet (u.v.) light were compared to those elicited by purinergic nerve stimulation and exogenous adenosine triphosphate (ATP).2 In the presence of sodium nitrite, u.v. light between 340-380 nm produced a maximum relaxation of the taenia coli. The relaxation was reversible and fast in onset. It was unaffected by atropine, guanethidine or low concentrations of phentolamine or propranolol. When the tone was low, the relaxation was usually followed by a ;rebound contraction' upon cessation of stimulation. Thus, the response to u.v. light closely resembles the responses to both purinergic nerve stimulation and exogenously applied ATP.3 U.v. light did not initiate impulses in purinergic nerves since its action was unaffected by tetrodotoxin; nor did it release ATP from nerve terminals (in contrast to its release during purinergic nerve stimulation). The adenosine-uptake inhibitor, dipyridamole, which potentiates the responses to purinergic nerve stimulation and ATP, did not affect the response to u.v. light.4 Agents known to alter postjunctional responses to purinergic nerve stimulation and ATP also altered the response to u.v. light. High concentrations of the 2-substituted imidazoline compounds, antazoline and phentolamine, which antagonize the responses to purinergic nerve stimulation and ATP, reduced the responses to u.v. irradiation. The prostaglandin synthesis inhibitor, indomethacin, which abolishes the ;rebound contraction' following stimulation of purinergic nerves, also blocks the ;rebound ;contraction' following u.v. irradiation. Increases in the K(+) concentration produced parallel changes in the inhibitory responses to u.v. light and purinergic nerve stimulation.5 U.v. light produced relaxation and inhibition of spontaneous activity of the rabbit portal vein (relaxed by ATP), but had no effect on the guinea-pig urinary bladder (contracted by ATP) and ureter (unaffected by ATP).6 It is suggested that u.v. light is acting on some part of the purinergic receptor complex which is involved in the mediation of inhibitory responses to ATP and purinergic nerve stimulation, and may therefore provide a way of investigating the chemistry of inhibitory purinergic receptors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-1121026, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-1149797, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-1177155, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-1204732, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-13109745, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-13702637, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-4147755, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-4339250, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-4344978, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-4351785, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-4363763, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-5316287, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-5328391, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-5499824, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-5655961, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-5824751, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-5942999, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-6054024, http://linkedlifedata.com/resource/pubmed/commentcorrection/623941-994531
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-302
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Comparison of the effects of ultraviolet light and purinergic nerve stimulation on the guinea-pig taenia coli.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro