Linked Life Data

6238883

Source:http://linkedlifedata.com/resource/pubmed/id/6238883

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1985-1-22
pubmed:abstractText
The interconversion of zearalenone and zearalenol by rat erythrocytes in vitro has been investigated. The major metabolite obtained by incubating zearalenone with erythrocytes or whole blood from Sprague-Dawley rats was alpha-zearalenol. beta-Zearalenol was also formed but at levels several times lower than those of alpha-zearalenol. In the cell-free haemolysate NADPH was much more effective than NADH as a co-factor in the reduction of zearalenone. The maximal transformation of zearalenone to zearalenol by haemolysates occurred at pH 8.0. Both NAD+ and NADP+ were effective as co-factors in the oxidation of alpha-zearalenol to zearalenone. However, only NADP+ was effective as a co-factor in the oxidation of beta-zearalenol. Conversion of alpha-zearalenol and beta-zearalenol to the corresponding epimer was observed in both erythrocyte suspensions and in cell-free haemolysates. The significance of these findings to the metabolism of zearalenone in vivo is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0278-6915
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
887-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Transformation of zearalenone and zearalenol by rat erythrocytes.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't