Linked Life Data

6238751

Source:http://linkedlifedata.com/resource/pubmed/id/6238751

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-1-9
pubmed:abstractText
The monoclonal antibody reactivity of cord blood mononuclear cells to six monoclonal reagents, OKT3, OKT4, OKT6, OKT8, OKT10, and OKT11, was evaluated using an indirect immunofluorescence technique. An immature population of cells was found; 24% of T cells in cord blood expressed OKT6 and 58% expressed OKT10. A previously undescribed phenotype, OKT3+/OKT6+, was discovered using double-labeling studies. In addition, the OKT4+:OKT8+ ratio in cord blood was 1:2, compared with 1:3 in the normal adult controls tested in this study. This is explained by the presence of a population of OKT4+/OKT8+ cells circulating in the neonate. Double-labeling studies of the cord blood samples demonstrated that all of the OKT3+ cells were simultaneously OKT11+ and that 17% of the cells were OKT11+ only. This is in accordance with the findings in normal adult peripheral T cells. Therefore, circulating neonatal T cells express an immature phenotype more characteristic of thymocytes and an altered OKT4+:OKT8+ ratio as compared with adult controls. We also describe a new phenotype OKT3+/OKT6+ present on the cord mononuclear cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0735-3111
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-10
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Recognition of immature T-cell phenotypes in neonatal blood using monoclonal antibodies.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't