| pubmed-article:6237710 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6237710 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6237710 | lifeskim:mentions | umls-concept:C0678222 | lld:lifeskim |
| pubmed-article:6237710 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:6237710 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:6237710 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:6237710 | pubmed:dateCreated | 1984-11-28 | lld:pubmed |
| pubmed-article:6237710 | pubmed:abstractText | Immune-deprived mice bearing HX99 human breast carcinoma xenografts were injected with a radiolabelled monoclonal antibody, LICR-LON-M8 (M8), to investigate the dependence of tumour localization on (i) tumour site and (ii) antibody radiolabel. No significant difference was found in the degree of localization of radio-iodinated M8 in subcutaneous, renal or intracranial xenografts, but a highly significant improvement in HX99 localization by M8 was recorded using an 111indium-DTPA conjugate of the antibody (111In-DTPA-M8), related to its rapid tumour uptake and blood pool clearance. Radio-iodinated or 111In-labelled M8 was given to 29 patients with breast cancer, 7 with primary tumours and 22 with metastases. Tumour localization was assessed by (i) examination of surgical specimens and (ii) antibody scans, which were compared with conventional X-rays and 99mTc-methylene diphosphonate (MDP) bone scans. Radiolabelled M8 localized preferentially in all primary tumours (radioactivity tumour: normal breast = 6.2 +/- 1.4 [mean +/- s.e.]). All ten patients with skeletal metastases had positive 111In-DTPA-M8 scans, but the correlation with X-rays and MDP scans showed a regional variation. Radio-iodinated M8 failed to identify metastases in any site. The favourable biodistribution of 111In-DTPA-M8 has led to the clear localization of breast carcinomas in patients and mice. In future such reagents may rationalize the clinical management of breast cancer. | lld:pubmed |
| pubmed-article:6237710 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6237710 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6237710 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6237710 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6237710 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6237710 | pubmed:issn | 0007-1323 | lld:pubmed |
| pubmed-article:6237710 | pubmed:author | pubmed-author:RainsburyR... | lld:pubmed |
| pubmed-article:6237710 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6237710 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:6237710 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6237710 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6237710 | pubmed:pagination | 805-12 | lld:pubmed |
| pubmed-article:6237710 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:6237710 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6237710 | pubmed:articleTitle | The localization of human breast carcinomas by radiolabelled monoclonal antibodies. | lld:pubmed |
| pubmed-article:6237710 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6237710 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6237710 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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