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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1984-11-28
|
| pubmed:abstractText |
Immune-deprived mice bearing HX99 human breast carcinoma xenografts were injected with a radiolabelled monoclonal antibody, LICR-LON-M8 (M8), to investigate the dependence of tumour localization on (i) tumour site and (ii) antibody radiolabel. No significant difference was found in the degree of localization of radio-iodinated M8 in subcutaneous, renal or intracranial xenografts, but a highly significant improvement in HX99 localization by M8 was recorded using an 111indium-DTPA conjugate of the antibody (111In-DTPA-M8), related to its rapid tumour uptake and blood pool clearance. Radio-iodinated or 111In-labelled M8 was given to 29 patients with breast cancer, 7 with primary tumours and 22 with metastases. Tumour localization was assessed by (i) examination of surgical specimens and (ii) antibody scans, which were compared with conventional X-rays and 99mTc-methylene diphosphonate (MDP) bone scans. Radiolabelled M8 localized preferentially in all primary tumours (radioactivity tumour: normal breast = 6.2 +/- 1.4 [mean +/- s.e.]). All ten patients with skeletal metastases had positive 111In-DTPA-M8 scans, but the correlation with X-rays and MDP scans showed a regional variation. Radio-iodinated M8 failed to identify metastases in any site. The favourable biodistribution of 111In-DTPA-M8 has led to the clear localization of breast carcinomas in patients and mice. In future such reagents may rationalize the clinical management of breast cancer.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Diphosphonates,
http://linkedlifedata.com/resource/pubmed/chemical/Indium,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Pentetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium Tc 99m Medronate
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0007-1323
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
805-12
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6237710-Animals,
pubmed-meshheading:6237710-Antibodies, Monoclonal,
pubmed-meshheading:6237710-Breast Neoplasms,
pubmed-meshheading:6237710-Diphosphonates,
pubmed-meshheading:6237710-Evaluation Studies as Topic,
pubmed-meshheading:6237710-Female,
pubmed-meshheading:6237710-Humans,
pubmed-meshheading:6237710-Indium,
pubmed-meshheading:6237710-Iodine Radioisotopes,
pubmed-meshheading:6237710-Mice,
pubmed-meshheading:6237710-Mice, Inbred BALB C,
pubmed-meshheading:6237710-Mice, Inbred CBA,
pubmed-meshheading:6237710-Neoplasm Metastasis,
pubmed-meshheading:6237710-Neoplasm Transplantation,
pubmed-meshheading:6237710-Organ Specificity,
pubmed-meshheading:6237710-Pentetic Acid,
pubmed-meshheading:6237710-Radioisotopes,
pubmed-meshheading:6237710-Scintillation Counting,
pubmed-meshheading:6237710-Technetium,
pubmed-meshheading:6237710-Technetium Tc 99m Medronate,
pubmed-meshheading:6237710-Transplantation, Heterologous
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
The localization of human breast carcinomas by radiolabelled monoclonal antibodies.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|