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rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0018894,
umls-concept:C0038856,
umls-concept:C0067787,
umls-concept:C0124604,
umls-concept:C0200932,
umls-concept:C0205263,
umls-concept:C0814999,
umls-concept:C1135166,
umls-concept:C1155229,
umls-concept:C1280500,
umls-concept:C1305923,
umls-concept:C1366556,
umls-concept:C1422172,
umls-concept:C1511938,
umls-concept:C1705513
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pubmed:issue |
2
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pubmed:dateCreated |
1984-11-9
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pubmed:abstractText |
Normal mice given thymocyte subpopulations preincubated with a proline-rich polypeptide (PRP) and immunized with SRBC show enhanced or suppressed humoral immune response measured by the number of plaque-forming cells (PFC). PRP induces differentiation of cells exhibiting helper or suppressive function from NAT and GAT respectively. Moreover, it was demonstrated that PRP-induced helper cells lost their activity after treatment with anti-Lyt 1,1 and the PRP-induced suppressor cells after treatment with anti-Lyt 2,1 monoclonal antibodies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0004-069X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-201
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6237628-Animals,
pubmed-meshheading:6237628-Antibodies, Monoclonal,
pubmed-meshheading:6237628-Antibody Formation,
pubmed-meshheading:6237628-Cell Adhesion,
pubmed-meshheading:6237628-Cell Differentiation,
pubmed-meshheading:6237628-Cells, Cultured,
pubmed-meshheading:6237628-Female,
pubmed-meshheading:6237628-Mice,
pubmed-meshheading:6237628-Mice, Inbred DBA,
pubmed-meshheading:6237628-Peptides,
pubmed-meshheading:6237628-Proline-Rich Protein Domains,
pubmed-meshheading:6237628-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:6237628-T-Lymphocytes, Regulatory
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pubmed:year |
1984
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pubmed:articleTitle |
The effect of a proline-rich polypeptide (PRP) on the humoral immune response. II. PRP induces differentiation of helper cells from glass-nonadherent thymocytes (NAT) and suppressor cells from glass-adherent thymocytes (GAT).
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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