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rdf:type |
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lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0017337,
umls-concept:C0032136,
umls-concept:C0050897,
umls-concept:C0080194,
umls-concept:C0086418,
umls-concept:C0205281,
umls-concept:C1159668,
umls-concept:C1440605,
umls-concept:C1709305,
umls-concept:C2700640
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pubmed:issue |
1
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pubmed:dateCreated |
1984-11-6
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pubmed:abstractText |
The aerobactin-mediated iron uptake system encoded by pColV-K30 and other ColV plasmids has been associated with the ability of Escherichia coli strains to cause disease. We investigated whether the pColV-K30 aerobactin system is present in E. coli K1 VW187 isolated from a human neonate with meningitis. This strain exhibited a functional aerobactin-mediated iron uptake system, as assessed by a cross-feeding bioassay and by its sensitivity to cloacin, a bacteriocin that recognizes the outer membrane receptor for iron-aerobactin complexes. By using a variety of techniques, we could not find any plasmid harboring the aerobactin genes. Hybridization of restriction endonuclease-cleaved chromosomal DNA from strain VW187 with various clones containing subsets of the pColV-K30 aerobactin region showed that the aerobactin genes were located on a 10.5-kilobase-pair chromosomal HindIII restriction fragment which also contained IS1-like insertion sequences. The chromosomal aerobactin region showed a high degree of conservation when compared with the homologous region in plasmid pColV-K30, although it was located on a different restriction endonuclease site environment.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-1100600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-131121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-14067100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-160892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-17247495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-338623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-352628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-363519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-363940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-379572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-383617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-388356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-4133095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-4313071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-4559594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-4604810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-4868353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-4896022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-49468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6090418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6090419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6106013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6198283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6218156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6274841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6292969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6296043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6313629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6330037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6455965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6456229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6752031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6995336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-6995437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-7011976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-7012838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-7042696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-7061401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-7366725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-881736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6237061-97269
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
159-67
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:6237061-Bacterial Outer Membrane Proteins,
pubmed-meshheading:6237061-Bacteriocin Plasmids,
pubmed-meshheading:6237061-Chromosomes, Bacterial,
pubmed-meshheading:6237061-Escherichia coli,
pubmed-meshheading:6237061-Genes, Bacterial,
pubmed-meshheading:6237061-Genetic Linkage,
pubmed-meshheading:6237061-Humans,
pubmed-meshheading:6237061-Hydroxamic Acids,
pubmed-meshheading:6237061-Iron,
pubmed-meshheading:6237061-Iron Chelating Agents,
pubmed-meshheading:6237061-Receptors, Immunologic,
pubmed-meshheading:6237061-Siderophores
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pubmed:year |
1984
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pubmed:articleTitle |
Aerobactin iron transport genes commonly encoded by certain ColV plasmids occur in the chromosome of a human invasive strain of Escherichia coli K1.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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