Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0002131,
umls-concept:C0003250,
umls-concept:C0003339,
umls-concept:C0017355,
umls-concept:C0024297,
umls-concept:C0033268,
umls-concept:C0039194,
umls-concept:C0205332,
umls-concept:C0439851,
umls-concept:C0591833,
umls-concept:C1280500,
umls-concept:C1522642,
umls-concept:C1552596,
umls-concept:C1947931
|
| pubmed:issue |
4
|
| pubmed:dateCreated |
1984-10-15
|
| pubmed:abstractText |
Monoclonal antibodies recognizing murine T lymphocyte cell surface structures implicated in T lymphocyte-mediated cytolysis, including Lyt-2, L3T4, LFA-1, and a cytolytic T lymphocyte (CTL) clonotypic determinant, were used as probes to investigate the role of these structures in lymphokine production by T cell clones induced by antigen or lectin. The clone-specific antibody 384.5 bound to and inhibited antigen-induced lymphokine production by the L3 CTL clone, but did not affect lymphokine production by other T cell clones. Antibodies against the T cell surface structures Lyt-2 or L3T4, which are expressed by mutually exclusive T cell subsets, inhibited antigen-induced lymphokine production by class I major histocompatibility complex (MHC) antigen-reactive CTL clones or an M1s-reactive helper T lymphocyte (HTL) clone, respectively. Antibody against the broadly distributed LFA-1 molecule inhibited antigen-induced lymphokine production by all of the clones tested. Lectin-induced lymphokine production by cloned T cells was not inhibited by the clonotypic antibody, anti-Lyt-2, or anti-LFA-1; slight inhibition of the HTL clone was observed with the anti-L3T4 antibody. None of these structures appear to be uniquely involved with a particular functional response. Our results suggest that each of these structures is involved with the interactions between the effector cell and the stimulating cell leading to lymphokine production.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
133
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2051-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6236262-Animals,
pubmed-meshheading:6236262-Antibodies, Monoclonal,
pubmed-meshheading:6236262-Antibody Specificity,
pubmed-meshheading:6236262-Antigens, Ly,
pubmed-meshheading:6236262-Antigens, Surface,
pubmed-meshheading:6236262-Clone Cells,
pubmed-meshheading:6236262-Cytotoxicity, Immunologic,
pubmed-meshheading:6236262-Histocompatibility Antigens,
pubmed-meshheading:6236262-Immune Tolerance,
pubmed-meshheading:6236262-Lymphocyte Activation,
pubmed-meshheading:6236262-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:6236262-Lymphokines,
pubmed-meshheading:6236262-Mice,
pubmed-meshheading:6236262-Mice, Inbred C57BL,
pubmed-meshheading:6236262-Mice, Inbred CBA,
pubmed-meshheading:6236262-Mice, Inbred DBA,
pubmed-meshheading:6236262-Rats,
pubmed-meshheading:6236262-T-Lymphocytes,
pubmed-meshheading:6236262-T-Lymphocytes, Helper-Inducer
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Effects of monoclonal antibodies directed against murine T lymphocyte cell surface antigens on lymphokine production by cloned T lymphocytes reactive with class I MHC or Mls alloantigens.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|