|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1984-10-3
|
|
pubmed:abstractText |
The effects of vanadate on intracellular Ca2+ sequestration and hexose transport were studied in Swiss 3T3 cells. Vanadate inhibited ATP-dependent Ca2+ uptake by saponin-permeabilized Swiss 3T3 cells at 10(-5) and 10(-7) M Ca2+ at which the Ca2+ uptake was sensitive and insensitive to oligomycin plus antimycin A, respectively. On the other hand, vanadate stimulated 2-deoxy-D-glucose (2DG) uptake in a dose- and time-dependent way. The stimulation of 2DG uptake by vanadate was inhibited by EGTA plus A23187 and the inhibition was reversed by Ca2+ restoration. These results suggest that an increase in cytosolic Ca2+ by inhibition of intracellular ATP-dependent Ca2+ sequestration by vanadate results in the stimulation of hexose transport in Swiss 3T3 cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimycin A,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Transporting ATPases,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxy Sugars,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyglucose,
http://linkedlifedata.com/resource/pubmed/chemical/Egtazic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligomycins,
http://linkedlifedata.com/resource/pubmed/chemical/Vanadates,
http://linkedlifedata.com/resource/pubmed/chemical/Vanadium
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
20
|
|
pubmed:volume |
174
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
71-5
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:6236103-Animals,
pubmed-meshheading:6236103-Antimycin A,
pubmed-meshheading:6236103-Calcium,
pubmed-meshheading:6236103-Calcium-Transporting ATPases,
pubmed-meshheading:6236103-Carrier Proteins,
pubmed-meshheading:6236103-Cell Membrane,
pubmed-meshheading:6236103-Cells, Cultured,
pubmed-meshheading:6236103-Deoxy Sugars,
pubmed-meshheading:6236103-Deoxyglucose,
pubmed-meshheading:6236103-Egtazic Acid,
pubmed-meshheading:6236103-Epidermal Growth Factor,
pubmed-meshheading:6236103-Fibroblasts,
pubmed-meshheading:6236103-Kinetics,
pubmed-meshheading:6236103-Mice,
pubmed-meshheading:6236103-Monosaccharide Transport Proteins,
pubmed-meshheading:6236103-Oligomycins,
pubmed-meshheading:6236103-Vanadates,
pubmed-meshheading:6236103-Vanadium
|
|
pubmed:year |
1984
|
|
pubmed:articleTitle |
Effects of vanadate on intracellular Ca2+ redistribution and hexose transport across plasma membrane in cultured mouse fibroblasts.
|
|
pubmed:publicationType |
Journal Article
|
