Linked Life Data

6235401

Source:http://linkedlifedata.com/resource/pubmed/id/6235401

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-8-29
pubmed:abstractText
Synthetic vascular grafts often occlude when used in low-flow high-resistance reconstructions. In order to study the pathophysiology of graft failure a flow-regulated ex vivo shunt was designed for insertion into the baboon femoral artery and vein. Synthetic graft materials (4 mm i.d.) can be placed into the shunt circuit and studied at known rates of flow for uptake of 111In-labeled platelets. Segments of the grafts can be removed from the shunt circuit at specified time intervals for morphologic study with scanning electron microscopy (SEM). In this paper the shunt model is described in detail and early experiments with it are reported. Labeled platelet uptake and SEM studies suggest that flow rate and graft composition influence the deposition of platelets and other blood components on graft surfaces. At high-flow knitted Dacron attracts large numbers of platelets, and becomes covered with a nearly confluent platelet-protein carpet within 1 hr. At low flow platelet uptake and development of the platelet-protein carpet is slower. Polytetrafluoroethylene (PTFE) attracts few platelets at high-flow rates, but at lower-flow rates begins to develop a platelet-protein carpet similar to that seen on knitted Dacron. Flow-related factors influencing platelet deposition are discussed and further experiments to be carried out with this model are described.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
112-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
A baboon flow-regulated shunt for the study of small caliber vascular grafts.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.