Linked Life Data

6233893

Source:http://linkedlifedata.com/resource/pubmed/id/6233893

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1984-7-16
pubmed:abstractText
Restenosis is recognized as a common complication of PTCA and can limit the long-term benefit of this procedure. To study the effect of antiplatelet agents in preventing restenosis, 25 New Zealand rabbits had bilateral iliac stenoses created by balloon deendothelialization and a 2% cholesterol diet for 6 weeks. After angiographic delineation of the iliac atherosclerosis, successful angioplasty was performed in all rabbits, with an average increase in luminal diameter of 0.9 mm (81%). Seven rabbits received aspirin (32 mg/day) plus dipyridamole (25 mg/day) and 9 received sulfinpyrazone (100 mg/day); 9 were given no antiplatelet drugs and served as controls. After 4 weeks of drug therapy and a continued atherogenic diet, angiography was repeated and the rabbits were killed for histologic examination. The angiographic luminal diameter was similar for these groups both before and immediately after angioplasty. However, the luminal diameter 4 weeks later was significantly larger in both the aspirin plus dipyridamole and the sulfinpyrazone groups compared with the control rabbits (1.3 +/- 0.6 and 1.8 +/- 0.5 mm vs 0.7 +/- 0.6 mm, respectively, p less than 0.05). Histologic examination revealed intraluminal clot in 4 of 9 control rabbits and in none of the drug-treated rabbits. Also, less intimal thickening was evident. In conclusion, aspirin plus dipyridamole and sulfinpyrazone inhibited angiographic restenosis after transluminal angioplasty in this experimental model. These findings support the use of antiplatelet agents in clinical angioplasty and suggest that platelet aggregation at the angioplasty site may promote restenosis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0002-9149
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
72C-76C
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effect of antiplatelet therapy on restenosis after experimental angioplasty.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.