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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1984-7-18
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pubmed:abstractText |
The effects of Ly-5 alloantisera on the generation of cytotoxic T cells (CTL), on the effector phase of CTL killing, and on polyclonal mitogenesis were studied. Ly-5 antisera added at the beginning of mixed lymphocyte culture (MLC) suppressed the production of CTL in an allele-specific manner. Neither Ly-5.1 nor Ly-5.2 antisera inhibited the generation of cytotoxic effectors by Ly-5.1/Ly-5.2 heterozygous spleen cells; however, a combination of Ly-5.1 and Ly-5.2 antisera markedly suppressed the appearance of Ly-5 heterozygous CTL. Similarly, Ly-5 antisera inhibited the effector phase of CTL killing in an allele-specific manner. In addition, Ly-5 alloantisera specifically blocked concanavalin A and oxidative mitogenesis of splenocytes carrying the appropriate Ly-5 alloantigen. The results are discussed in light of a possible functional role of Ly-5 molecules in immune processes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6233370-Animals,
pubmed-meshheading:6233370-Antigens, Ly,
pubmed-meshheading:6233370-Antilymphocyte Serum,
pubmed-meshheading:6233370-Binding, Competitive,
pubmed-meshheading:6233370-Concanavalin A,
pubmed-meshheading:6233370-Female,
pubmed-meshheading:6233370-Galactose Oxidase,
pubmed-meshheading:6233370-Isoantigens,
pubmed-meshheading:6233370-Lymphocyte Activation,
pubmed-meshheading:6233370-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:6233370-Male,
pubmed-meshheading:6233370-Mice,
pubmed-meshheading:6233370-Mice, Inbred BALB C,
pubmed-meshheading:6233370-Mice, Inbred C57BL,
pubmed-meshheading:6233370-Mice, Inbred CBA,
pubmed-meshheading:6233370-Mitogens,
pubmed-meshheading:6233370-Neuraminidase,
pubmed-meshheading:6233370-T-Lymphocytes, Cytotoxic
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pubmed:year |
1984
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pubmed:articleTitle |
Inhibition of T cell responses to alloantigens and polyclonal mitogens by Ly-5 antisera.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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