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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1984-5-30
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pubmed:abstractText |
Ninety-five diffuse large cell lymphomas in 89 patients were stained in cryostat sections with a panel of monoclonal antibodies. Lymphoma cells from 47 patients (53%) expressed either kappa or lambda light chains, usually in combination with mu heavy chains. Fifteen samples from 12 patients (14%) expressed two or more T-cell antigens and commonly expressed Ia antigens. Lymphoma cells from 10 of these patients uniformly lacked one or more pan T-cell antigens; lymphoma cells from 4 of these patients also lacked both T-subset antigens--findings which should prove useful in diagnosis. Lymphomas from 28 patients (31%) did not express immunoglobulin or T-cell antigens but commonly expressed the B-lineage antigen B1; and the remaining 9 cases generally expressed Ia antigens, common ALL antigens, or both. Our findings confirm the marked immunologic heterogeneity of diffuse large cell lymphomas; the phenotypic heterogeneity observed in T-cell cases in many instances is difficult to reconcile with current models of T-cell differentiation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-1089792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-1201238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-214220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-304674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-311589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-356957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-362206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-415608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-4608683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-46388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-6273911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-63805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-6456062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-6576991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-6603882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-6766752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-6770268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-6781554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-6784790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-6965562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-6974808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-6982414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-7013967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-7024458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-7041360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-7042005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6232854-768505
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6232854-Antibodies, Monoclonal,
pubmed-meshheading:6232854-B-Lymphocytes,
pubmed-meshheading:6232854-Histocompatibility Antigens Class II,
pubmed-meshheading:6232854-Histocytochemistry,
pubmed-meshheading:6232854-Humans,
pubmed-meshheading:6232854-Immunoenzyme Techniques,
pubmed-meshheading:6232854-Immunoglobulin Light Chains,
pubmed-meshheading:6232854-Immunoglobulin kappa-Chains,
pubmed-meshheading:6232854-Immunoglobulin lambda-Chains,
pubmed-meshheading:6232854-Immunoglobulin mu-Chains,
pubmed-meshheading:6232854-Lymphoma,
pubmed-meshheading:6232854-Phenotype,
pubmed-meshheading:6232854-T-Lymphocytes,
pubmed-meshheading:6232854-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:6232854-T-Lymphocytes, Regulatory
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pubmed:year |
1984
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pubmed:articleTitle |
The immunologic characterization of 95 nodal and extranodal diffuse large cell lymphomas in 89 patients.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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