Linked Life Data

6231484

Source:http://linkedlifedata.com/resource/pubmed/id/6231484

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5957
pubmed:dateCreated
1984-5-2
pubmed:abstractText
The activation of some subsets of T cells requires the recognition of antigen in association with self Ia determinants. It is not clear, however, whether this is also necessary for the induction of unresponsiveness and the active suppression of hapten-specific T cells. We have studied the regulation of the delayed-type hypersensitivity (DTH) response in mice. Subcutaneous (s.c.) injection of haptenated syngeneic cells primarily activates T helper cells, while intravenous (i.v.) injection results in unresponsiveness and the activation of T suppressor cells. Presentation of antigen by an I-A-positive antigen-presenting cell (APC) seems to be critical for T helper cell activation. We now show that the activation of first-order T suppressor cells requires the presentation of hapten on an I-J-positive APC. However, i.v. injection of I-J-depleted haptenated cells also results in hepten-specific unresponsiveness. This non-transferable T-cell tolerance requires the presence of an I-A-positive APC and is genetically restricted. These results suggest that distinct modes of antigen presentation and administration are required for immunity, suppression and non-transferable tolerance.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
308
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
373-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Genetically restricted antigen presentation for immunological tolerance and suppression.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't