Linked Life Data

6229909

Source:http://linkedlifedata.com/resource/pubmed/id/6229909

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-3-14
pubmed:abstractText
The effect of mefloquine-HCL, a new 4-quinoline methanol anti-malarial compound, on in vitro blast transformation of human peripheral blood mononuclear cells (MNC) was studied. Mefloquine significantly suppressed lectin-induced blast transformation of MNC from healthy Thai adults but MNC responsiveness in the mixed leucocyte reaction (MLR) and cellular viability were not reduced by the concentrations of mefloquine studied. Both T and non-T MNC responsiveness was lower in cultures containing the drug than in normal control cultures. The addition of serum from individuals on mefloquine chemoprophylaxis caused no significant suppression in the blast transformation assays or the MLR but the data do not rule out any clinically significant in vivo suppressive effect by mefloquine on human cellular immune response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0035-9203
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
767-70
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Inhibition of mitogenic lectin induced blast transformation in human peripheral blood mononuclear cells by mefloquine.
pubmed:publicationType
Journal Article