Linked Life Data

6229407

Source:http://linkedlifedata.com/resource/pubmed/id/6229407

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1984-3-12
pubmed:abstractText
The autologous mixed lymphocyte reaction (AMLR) is thought to represent the in vitro proliferation of T cells in response to stimulation by autologous histocompatibility antigens present on non-T cells. We have investigated the possibility that xenogeneic determinants act as the stimulating antigens in the human AMLR. Exposure of lymphocytes to fetal calf serum and/or sheep red blood cells during fractionation triggers substantial proliferation of T cells, plaque-forming cell responses, and interleukin 2 production. In contrast, lymphocytes isolated and cultured in the absence of any known foreign substances failed to respond in the AMLR, yet responded significantly when cultured in the presence of fetal calf serum. These results suggest that without exposure to foreign antigens, the human AMLR is difficult to demonstrate in vitro.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1031-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Failure of the human autologous mixed lymphocyte reaction in the absence of foreign antigens.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.