Linked Life Data

6229267

Source:http://linkedlifedata.com/resource/pubmed/id/6229267

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-3-20
pubmed:abstractText
Hairless mice were treated topically with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to induce experimental chloracne. The aryl hydrocarbon hydroxylase (AHH) activity in the epidermis was monitored. TCDD is a potent inducer of AHH activity in normal skin. However, as continued TCDD application induced hyperproliferative and hyperkeratotic changes in the epidermis, the AHH activity decreased. Similar suppression in AHH activity was demonstrated in epidermis made hyperplastic by (a) tape stripping of stratum corneum and (b) repeated application of 50% oleic acid. This suggests that the epidermal AHH response varies with the state of epidermal differentiation. In the hairless mouse, AHH activity in hyperplastic epidermis is lower than that in normal epidermis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0007-0963
pubmed:author
pubmed:issnType
Print
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-35
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Decreased induction of aryl hydrocarbon hydroxylase activity in hyperproliferative hairless mouse epidermis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.