| pubmed-article:6228697 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6228697 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6228697 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
| pubmed-article:6228697 | lifeskim:mentions | umls-concept:C1273518 | lld:lifeskim |
| pubmed-article:6228697 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:6228697 | lifeskim:mentions | umls-concept:C1327439 | lld:lifeskim |
| pubmed-article:6228697 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:6228697 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:6228697 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6228697 | pubmed:dateCreated | 1984-2-24 | lld:pubmed |
| pubmed-article:6228697 | pubmed:abstractText | Age-related changes in the processes involved in T cell dependent polyclonal B cell activation in man were studied by comparing immunoglobulin (Ig) produced in autologous T:B (E+:E-) cell cultures of young and old donor pairs with Ig produced in crossover cultures. Each young and old donor was classified as a responder or a non-responder based on Ig levels in autologous pokeweed mitogen-activated T:B cultures. The data indicate that: (1) T suppressor influences are a major determinant of non-response in the young; (2) T cells of nonresponder old donors can support high levels of Ig secretion by young donors' B cells; (3) low response to pokeweed mitogen stimulation in the elderly may reflect either direct refractoriness of B cells to T cell dependent stimulation, heightened B cell sensitivity to suppressor signals, or a combination of the two. | lld:pubmed |
| pubmed-article:6228697 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6228697 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6228697 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6228697 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6228697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6228697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6228697 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6228697 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6228697 | pubmed:issn | 0047-6374 | lld:pubmed |
| pubmed-article:6228697 | pubmed:author | pubmed-author:ArnasonB GBG | lld:pubmed |
| pubmed-article:6228697 | pubmed:author | pubmed-author:HopperJ EJE | lld:pubmed |
| pubmed-article:6228697 | pubmed:author | pubmed-author:AntelJ PJP | lld:pubmed |
| pubmed-article:6228697 | pubmed:author | pubmed-author:OgezJ RJR | lld:pubmed |
| pubmed-article:6228697 | pubmed:author | pubmed-author:WrabetzL GLG | lld:pubmed |
| pubmed-article:6228697 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6228697 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:6228697 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6228697 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6228697 | pubmed:pagination | 11-9 | lld:pubmed |
| pubmed-article:6228697 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6228697 | pubmed:meshHeading | pubmed-meshheading:6228697-... | lld:pubmed |
| pubmed-article:6228697 | pubmed:meshHeading | pubmed-meshheading:6228697-... | lld:pubmed |
| pubmed-article:6228697 | pubmed:meshHeading | pubmed-meshheading:6228697-... | lld:pubmed |
| pubmed-article:6228697 | pubmed:meshHeading | pubmed-meshheading:6228697-... | lld:pubmed |
| pubmed-article:6228697 | pubmed:meshHeading | pubmed-meshheading:6228697-... | lld:pubmed |
| pubmed-article:6228697 | pubmed:meshHeading | pubmed-meshheading:6228697-... | lld:pubmed |
| pubmed-article:6228697 | pubmed:meshHeading | pubmed-meshheading:6228697-... | lld:pubmed |
| pubmed-article:6228697 | pubmed:meshHeading | pubmed-meshheading:6228697-... | lld:pubmed |
| pubmed-article:6228697 | pubmed:meshHeading | pubmed-meshheading:6228697-... | lld:pubmed |
| pubmed-article:6228697 | pubmed:meshHeading | pubmed-meshheading:6228697-... | lld:pubmed |
| pubmed-article:6228697 | pubmed:meshHeading | pubmed-meshheading:6228697-... | lld:pubmed |
| pubmed-article:6228697 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6228697 | pubmed:articleTitle | Mechanisms responsible for reduced in vitro immunoglobulin secretion in aged humans. | lld:pubmed |
| pubmed-article:6228697 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6228697 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6228697 | lld:pubmed |
