Linked Life Data

6228697

Source:http://linkedlifedata.com/resource/pubmed/id/6228697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-2-24
pubmed:abstractText
Age-related changes in the processes involved in T cell dependent polyclonal B cell activation in man were studied by comparing immunoglobulin (Ig) produced in autologous T:B (E+:E-) cell cultures of young and old donor pairs with Ig produced in crossover cultures. Each young and old donor was classified as a responder or a non-responder based on Ig levels in autologous pokeweed mitogen-activated T:B cultures. The data indicate that: (1) T suppressor influences are a major determinant of non-response in the young; (2) T cells of nonresponder old donors can support high levels of Ig secretion by young donors' B cells; (3) low response to pokeweed mitogen stimulation in the elderly may reflect either direct refractoriness of B cells to T cell dependent stimulation, heightened B cell sensitivity to suppressor signals, or a combination of the two.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0047-6374
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Mechanisms responsible for reduced in vitro immunoglobulin secretion in aged humans.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.